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Reactions of 2,2-difluoroalkenylboranes with halogens in the presence of base. Novel syntheses of symmetrically disubstituted 1,1-difluoro-1-alkenes and 1,1-difluoro-2-iodo-1-alkenes

✍ Scribed by Junji Ichikawa; Takaaki Sonoda; Hiroshi Kobayashi

Publisher
Elsevier Science
Year
1989
Tongue
French
Weight
171 KB
Volume
30
Category
Article
ISSN
0040-4039

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✦ Synopsis

Treatment of 2,2-difluoroalkenylboranes with bromine and iodine causes coupling reaction and halogenolysis to afford the title compounds in a reverse manner to nonfluorinated counterpart.

πŸ“œ SIMILAR VOLUMES

Highly regio- and stereocontrolled halog
Highly regio- and stereocontrolled halogenation of 1,1-difluoro-2-halo-1-alken-3-ols as applied to polyfluorinated pyrethroid synthesis
✍ Makoto Fujita; Tamejiro Hiyama πŸ“‚ Article πŸ“… 1986 πŸ› Elsevier Science 🌐 French βš– 125 KB

Treatment of l,1-difluoro-2-halo-l-alken-3-ols with various halogenating reagents gave(Z)-l,l-difluoro-1,2-dihalo-2-alkenes under high regio-and stereocontrol. This transformation was applied to the construction of C-3 side chain CH=C(X)CF2X' (X, X' = F or Cl) of polyfluorinated synthetic pyrethroid