Reactions between pyrrole and orthoesters: preparation of tri-(pyrrol-2-yl)alkanes

✍ Scribed by Colin B Reese; Hongbin Yan

• Book ID: 104231092
• Publisher: Elsevier Science
• Year: 2001
• Tongue: French
• Weight: 65 KB
• Volume: 42
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)01031-0

✦ Synopsis

Reactions between triethyl orthoformate, trimethyl orthoacetate and triethyl orthopropionate with pyrrole and chloroacetic acid lead to moderate yields of the corresponding tri-(pyrrol-2-yl)alkanes 5a, 5b and 5c, respectively. Under the same conditions, trimethyl orthobenzoate reacts with pyrrole and dichloroacetic acid to give the dipyrrin 7 in a relatively good yield.