✦ LIBER ✦
Reaction of zirconocene dichloride with alkyllithiums or alkyl grignard reagents as a convenient method for generating a “zirconocene” equivalant and its use in zirconium-promoted cyclization of alkenes, alkynes, dienes, enynes, and diynes
✍ Scribed by Ei-ichi Negishi; Fredrik E Cederbaum; Tamotsu Takahashi
- Publisher
- Elsevier Science
- Year
- 1986
- Tongue
- French
- Weight
- 225 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
Treatment of Cl2ZrCp2 with 2 equiv of alkylmetals (RM) containing Li or Mg, e.g., n-BuLi, in THF produces organozirconium species that act as sources of "ZrCp2," the latter product being a convenient reagent for preparing zirconacycles.
We recently reported a bicyclization reaction of enynes3 with a reagent generated by treating C12ZrCp2 with Mg (10 equiv) and HgC12 (1 equiv).4