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Reaction of tritium atoms with unsaturated compounds

✍ Scribed by Richard Lee E. Ehrenkaufer; Alfred P. Wolf; Wylie C. Hembree; Seymour Lieberman

Publisher
John Wiley and Sons
Year
1977
Tongue
French
Weight
270 KB
Volume
13
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The reaction of tritium atoms with unsaturated compounds was shown to proceed both by addition to the double bond yielding the reduced product as well as by tritium/hydrogen exchange resulting in labeled parent. Reduction occurred to varying degrees in all cases investigated but appears to be far less significant than in Wilzbach labeling. The addition/substitution ratio producing labeled products for oleic acid was 2.6(compared to 24.4 by Wilzbach) for the unsaturated amino acids 3,4‐dehydro‐D,L‐proline and L‐2‐amino‐4‐(2′‐aminoethoxy) trans‐3‐butenoic acid was 12.8 and 11.6 respectively and for morphine (resulting in 6,7‐dihydromorphine) only 0.02.

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