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Reaction of steroidal alcohols with isobutene. Usefulness of t-butyl as a hydroxyl-protecting group in a synthesis of testosterone

✍ Scribed by H. C. Beyerman; G. J. Heiszwolf


Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
574 KB
Volume
84
Category
Article
ISSN
0165-0513

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The use of triethylsilane as a carbocation scavenger in the presence of trifluoroacetic acid in dichloromethane leads to increased yields, decreased reaction times, simple work-up and improved selectivity for the deprotection of t-butyl ester and t-butoxycarbonyl sites in protected amino-acids and p