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Reaction of Functionalized Carbodiimide with α-Amino Ester: A Selective Synthesis of 2,3,5-Trisubstituted Imidazol-4-ones

✍ Scribed by Li, Hong-Xia; Sun, Yong; Ding, Ming-Wu


Book ID
121003111
Publisher
Taylor and Francis Group
Year
2008
Tongue
English
Weight
188 KB
Volume
38
Category
Article
ISSN
0039-7911

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To access mimics of peptidal ~-strands (1), scalemic 3,5,5-trisubstituted pyrrolin-4-ones bearing the tyrosine, serine, and lysine side-chains have been generated via cyclization of metalated imino esters and deprotection. The functionalized imino esters were prepared by asymmetric alkylation of a c