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Reaction of alkyl isocyanides and dialkyl acetylenedicarboxylates in the presence of 5,5-diaryl thiohydantoins. Synthesis of functionalized imidazo[2,1-b][1,3]thiazines

โœ Scribed by Ghanbari, Mohammad Mehdi; Yavari, Issa; Batta, Gyula


Book ID
126179981
Publisher
Taylor and Francis Group
Year
2014
Tongue
English
Weight
160 KB
Volume
35
Category
Article
ISSN
1741-5993

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First synthesis and further functionaliz
โœ Clemens Lamberth; Florian Querniard ๐Ÿ“‚ Article ๐Ÿ“… 2008 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 107 KB

A convenient four-step preparation route to novel 7-chloro-imidazo[2,1-b][1,3]thiazin-5-ones is presented, starting from methyl phenylglyoxylate. A unique feature of this synthesis is a heterocyclization strategy, in which a halogen atom is introduced already during the ring closure. 7-Chloro-6-phen