✦ LIBER ✦
Reaction of 4′-Benzyloxy-2-(4-pyridinyl)acetophenone with Ethylmagnesium Chloride: Unusual C-Benzylation and in situ Reduction by β-Hydrogen Transfer
✍ Scribed by Haroutounian, Serkos A. ;Couladouros, Elias A.
- Book ID
- 102368258
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 279 KB
- Volume
- 1996
- Category
- Article
- ISSN
- 0947-3440
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✦ Synopsis
Abstract
In solution, 4′‐benzyloxy‐2‐(4‐pyridinyl)acetophenone (1) mainly exists as enol 4 which does not undergo typical Grignard addition reactions. Treatment with an excess of ethylmagnesium chloride, however, initiates an unusual sequence of transformations leading to formation of the C‐benzylated compounds 2 and 3.