Reaction of 4-aryl-2-methylbut-3-yn-2-ols with thiourea as a new approach to the synthesis of 4-arylmethylidene-5,5-dimethyl-4,5-dihydrothiazole-2-amines
✍ Scribed by Baranov, D. S.; Mamatyuk, V. I.; Gatilov, Yu. V.; Vasilevsky, S. F.
- Book ID
- 120527356
- Publisher
- Springer
- Year
- 2012
- Tongue
- English
- Weight
- 247 KB
- Volume
- 61
- Category
- Article
- ISSN
- 1573-9171
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📜 SIMILAR VOLUMES
## Abstract For Abstract see ChemInform Abstract in Full Text.
## Abstract The model morpholine‐1‐carbothioic acid (2‐phenyl‐3__H__‐quinazolin‐4‐ylidene) amide (1) reacts with phenacyl bromides to afford __N__^4^‐(5‐aryl‐1,3‐oxathiol‐2‐yliden)‐2‐phenylquinazolin‐4‐amines (4) or __N__^4^‐(4,5‐diphenyl‐1,3‐oxathiol‐2‐yliden)‐2‐phenyl‐4‐aminoquinazoline (**5**) b
## Abstract The 5(4__H__)‐oxazolones 1a–e react with 5‐morpholinoisoxazoles 2a–b to afford the 4‐[(4‐isoxazolyl)methyl]‐5(4__H__)‐oxazolones 3a–g. Compounds 3 are hydrogenated with Pd/C in dioxane to yield the corresponding 1,4,5,6‐tetrahydro‐6‐oxo‐3‐pyridinecarbaldehydes 6a–d.
Reaction of N-aryl substituted maleimides with aliphatic ketazines leads to the formation of 4,5-dihydropyridazin-3(2H)-ones in moderate yields. The reaction proceeds through 1,4-addition of an azine to the maleimide double bond, as confirmed by separation of the corresponding adducts in some cases,