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Reaction of 4-acetoxy-1,4-benzoxazin-3-one with DNA. A possible chemical mechanism for the antifungal and mutagenic activities

✍ Scribed by Takayoshi Ishizaki; Yuichi Hashimoto; Koichi Shudo; Toshihiko Okamoto

Publisher: Elsevier Science
Year: 1982
Tongue: French
Weight: 132 KB
Volume: 23
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)88694-3

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✦ Synopsis

A reaction of 4-acetoxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one with DNA and nucleotldes was described. The N4 posltlon of the benzoxazlnone reacted with the C8 position of the guanlne residue of DNA and guanyllc acid. A group of 1,4-benzoxazln-3-ones was isolated from Job's tears, rye, wheat, and corn.' Derivatives of 2,4-dlhydroxy-1,4-benzoxazln-3-one occur as glycosldes from which the aglycones are rapidly released by enzymatic hydolysis after physical and blologlcal inJury of the plants.

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