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Reaction of 2-bromo-2-alkenoic carbonyl compounds with amidines: Part 2. Theoretical (PM3) studies of the mechanism of heterocyclization into dihydroimidazole and pyrimidin-4-(3H)-one

โœ Scribed by Pascale Friant-Michel; Jean-Louis Rivail; Alain Marsura


Book ID
113258407
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
660 KB
Volume
337
Category
Article
ISSN
0166-1280

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N-t-Butylacetamidines 1 on heating with methyl vinyl ketone, acrolein or crotonaldehyde gave the 2,3-dihydropyridine derivatives 4, 5 or 6 via N-alkylation of the acetamidines 1. Reaction of amidines 1 with phenyl 1-propenyl ketone, benzalacetone or chalcone gave 3,4-dihydropyridine derivatives 8, 9