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Reaction of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) with guanosine: Evidence for a new mechanism of DNA modification

โœ Scribed by Scott Parker; Marion C. Kirk; David B. Ludlum; R. Rao Koganty; J. William Lown


Book ID
117056904
Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
278 KB
Volume
139
Category
Article
ISSN
0006-291X

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Eighteen patients with unresectable bronchogenic carcinoma were treated with amphotericin B (7.5 mgim' on day I , I5 mg/m2 on day 2, and 30 mg/m2 on days 3 and 4) plus BCNU (250 mg/m2 on day 4 following amphotericin B) with courses of therapy repeated every 8 weeks. All patients had metastatic disea