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Reaction of 1,2-trans-glycosyl acetates with phosphorus pentachloride: new efficient approach to 1,2-trans-glycosyl chlorides

โœ Scribed by Farid M Ibatullin; Stanislav I Selivanov


Book ID
104252567
Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
106 KB
Volume
43
Category
Article
ISSN
0040-4039

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Disarmed glycosyl trichloroacetimidates can be activated by Yb(OTf) 3 in the synthesis of 1,2-trans glycosides involving primary and secondary acceptors. Concurrent formation of orthoester side products can be avoided by the use of alkoxycarbonyl groups for the protection of the donor 2-hydroxyl.