✦ LIBER ✦

Reaction between 5-(phenoxymethyl)-2-amino-2-oxazoline and N-benzyl-3-(ethoxycarbonyl)-4-piperidinone hydrochloride: A structural investigation

✍ Scribed by Isabelle Forfar; Christian Jarry; Michel Laguerre; Jean-Michel Léger; Isabelle Pianet

Publisher: Elsevier Science
Year: 1999
Tongue: French
Weight: 462 KB
Volume: 55
Category: Article
ISSN: 0040-4020
DOI: 10.1016/s0040-4020(99)00787-5

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✦ Synopsis

a]pyrido [3,4-e]pyrimidin-5-one 4 were synthesized by a one-step cyclocondensation from 5-(phenoxymethyl)-2-amino-2-oxazoline 1 with N-benzyl-3-(ethoxycarbonyl)-4-piperidinone hydrochloride 2. Their structures were assigned by comparison of two dimensional NMR spectra (HMBC, NOESY) with the results obtained from theoretical calculations. The structure of one related hydrolysis compound was established using X-ray crystallography, allowing to further confirm the structure assignment.