Treatment of patients with chronic hepatitis C has had limited success because of relapses and nonresponse to interferon alfa therapy (currently the only established therapeutic agent). A retrospective study was done to determine the efficacy of re-treatment with interferon and the predictors of res
Re-treatment of chronic hepatitis C with consensus interferon
β Scribed by E. Jenny Heathcote; Emmet B. Keeffe; Samuel S. Lee; Saya V. Feinman; Myron J. Tong; K. R. Reddy; Karsten Witt; Lawrence M. Blatt
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 106 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0270-9139
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AND THE CONSENSUS INTERFERON STUDY GROUP 15 tion. Efficacy was assessed by normalization of serum alanine This multicenter, randomized, controlled, double-blind, transaminase (ALT) concentration and decrease in serum hepphase III study in 704 patients with chronic hepatitis C infecatitis C virus (HC
Patients with chronic hepatitis C who have not had a sustained hepatitis C virus (HCV)-RNA response or serum alanine transaminase (ALT) response to a 6-month course of interferon (IFN) may respond to higher dose retreatment with consensus interferon (CIFN). Some nonresponders to initial IFN treatmen
The long-term benefit of interferon therapy in chronic hepatitis C is limited. During therapy, serum alanine aminotransferase (ALT) levels decrease to normal and hepatitis C virus (HCV) RNA decreases in 40% to 60% of patients. However, most patients relapse after therapy withdrawal, so that no more
Chronic hepatitis C is an insidious disease associated with prior interferon therapy were more likely to have a serum HCV RNA end-of-retreatment and sustained response than significant morbidity and mortality. Currently, the only approved therapies for chronic hepatitis C are the alpha interfer-pati
Twelve children with chronic non-A, non-B hepatitis were entered in a pilot trial of recombinant interferon-alpha. Although all the children had hepatitis C virus RNA in serum, only five had antibodies against this virus. Children received 3 MU/m2 body surface area interferon-alpha 3 times/wk for 6