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Re: Prenatal diagnosis of lissencephaly: A case report

✍ Scribed by Ankur Gadodia; Prerna Gupta; Raju Sharma;; Sunesh Kumar,


Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
77 KB
Volume
39
Category
Article
ISSN
0091-2751

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Prenatal diagnosis of lissencephaly: A c
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## Abstract We describe the abnormal sonographic findings in the brain of a 26‐week fetus, which increased the suspicion of isolated lissencephaly. Follow‐up ultrasound examination and MRI depicted diffuse cortical agyria, microcephaly, hypotelorism, and proptosis. Cordocentesis showed a normal 46,

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Lissencephaly is a rare developmental disorder resulting from impaired neural migration occurring from 6 to 15 weeks' gestation.' In its most severe form, it results in complete absence of gyri and sulci, and is called agyria. In other cases, there may be only a few abnormal gyri. Prenatal diagnosis

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While the clinical features associated with full trisomy 13 have been well characterized, the clinical outcome associated with mosaic trisomy 13 is much less clear. The medical literature reports a broad range of possible clinical outcomes from severe mental retardation and birth defects to normal i