Cell surface expression of HLA class I/peptide complexes on tumor cells is a key step in the generation of T-cell-based immune responses. Several genetic defects underlying the lack of HLA class I expression have been characterized. Here we describe another molecular mechanism that accounts for the
✦ LIBER ✦
Re-expression of HLA class I antigens and restoration of antigen-specific cytotoxic T lymphocytes in melanoma cells following 5-AZA-2′deoxycytidine treatment
✍ Scribed by Esparza, C.; Mendez, R.; Jurado, J.M.; Serrano, A.; Martinez, J.; Hernandez, V.; Ruiz-Cabello, F.; Garrido, F.
- Book ID
- 121910379
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 332 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0959-8049
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## Abstract Cancer vaccines directed against tumor associate antigen (TAA) have produced encouraging results in preclinical models but not in cancer patients. A major limitation of this strategy is the relative degree of tolerance to these antigens and the low and heterogeneous tumor cell expressio