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Re-expression of differentiated proteoglycan phenotype by dedifferentiated human chondrocytes during culture in alginate beads

✍ Scribed by Hongxiang Liu; Yee-Wah Lee; MichaelF. Dean

Book ID
117481744
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
297 KB
Volume
1425
Category
Article
ISSN
0304-4165

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Chondrocytes cultivated in monolayer rapidly divide and lose their morphological and biochemical characteristics, whereas they maintain their phenotype for long periods of time when they are cultivated in alginate beads. Because cartilage has a low cellularity and is difficult to obtain in large qua