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Proteins containing non-native disulfide

Proteins containing non-native disulfide bonds generated by oxidative stress can act as signals for the induction of the heat shock response

✍ Alice T. McDuffee; Guillermo Senisterra; Steven Huntley; James R. Lepock; Konjet 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 206 KB 👁 1 views

While oxidative stress can induce a heat shock response, the primary signals that initiate activation have not been identified. To identify such signals, HepG2 and V 79 cells were exposed to menadione, a compound that redox-cycles to generate superoxide. The oxidative stress generated by menadione r