✦ LIBER ✦
RCAI-61, the 6′-O-methylated analog of KRN7000: its synthesis and potent bioactivity for mouse lymphocytes to produce interferon-γ in vivo
✍ Scribed by Takuya Tashiro; Ryusuke Nakagawa; Sayo Inoue; Masao Shiozaki; Hiroshi Watarai; Masaru Taniguchi; Kenji Mori
- Book ID
- 104095841
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- French
- Weight
- 189 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
RCAI-61, the 6 0 -O-methylated analog of KRN7000, and six other analogs with modified 6 0 -position of the galactose moiety of KRN7000 were synthesized to examine their bioactivity for mouse lymphocytes.
Methyl a-D-galactopyranoside was the starting material for RCAI-58, 61, 64, 83, 85, and 86, while RCAI-87 was prepared from methyl b-L-arabinopyranoside. Bioassay showed RCAI-61 to be a much more potent stimulant of mouse lymphocytes than KRN7000 and RCAI-56 to induce the production of a large amount of IFN-c in vivo.