Mutations in both alleles of the RB1 gene are causal for the development of retinoblastoma, a childhood tumor of the eye. The spectrum of somatic and germline mutations in this gene is dominated by small mutations. Data on small mutations are listed in a locus specific database available at http://w
RB1 gene mutations in retinoblastoma and its clinical correlation
β Scribed by Mohammad Javed Ali; Vidya Latha Parsam; Santosh G. Honavar; Chitra Kannabiran; Geeta K. Vemuganti; Vijay Anand P. Reddy
- Book ID
- 116883508
- Publisher
- Elsevier
- Year
- 2010
- Tongue
- English
- Weight
- 312 KB
- Volume
- 24
- Category
- Article
- ISSN
- 1319-4534
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We have analyzed the 27 exons and the promoter region of the RBI gene in familial or sporadic bilateral retinoblastoma by using single-strand conformation polymorphism analysis. For improvement over previous studies, a new set of primers has been designed, which allow for amplification of the coding