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Rb and Tumorigenesis

✍ Scribed by Maurizio Fanciulli Ph.D. (auth.)


Publisher
Springer US
Year
2006
Tongue
English
Leaves
128
Series
Molecular Biology Intelligence Unit
Edition
1
Category
Library

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✦ Synopsis


Rb and Tumorigenesis examines how recent advances have demonstrated the interaction of Rb with chromatin remodeling enzymes. This new title explores the potential roles of these interactions in Rb functions and provides some evidence that distinct Rb co-repressor may target different genes in different phases of the cell cycle.

✦ Table of Contents


RB as a Positive Transcriptional Regulator during Epithelial Differentiation....Pages 1-10
pRb in the Differentiation of Normal and Neoplastic Cells....Pages 11-19
Regulation of DNA Replication by the Retinoblastoma Tumor Suppressor Protein....Pages 20-36
New Insights into Transcriptional Regulation by Rb....Pages 37-45
Regulation of Rb Function by Noncyclin Dependent Kinases....Pages 46-58
Diverse Regulatory Functions of the E2F Family of Transcription Factors....Pages 59-72
Regulation of E2F-Responsive Genes through Histone Modifications....Pages 73-80
Emerging Roles for the Retinoblastoma Gene Family....Pages 81-105
Rb and Cellular Differentiation....Pages 106-117

✦ Subjects


Cell Biology; Molecular Medicine; Immunology


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