โ Scribed by Schlagel, Carl A. ;Nelson, John W.
No coin nor oath required. For personal study only.
Four groups of dogs, each with surgically different backgrounds were given 1.0 mg./Kg. of alseroxylon alkaloids intravenously and observed for six hours for changes in blood pressure, heart rate, and carotid occlusion reflex responses. The same degree of bradycardia was observed in each of the four groups of animals. However, the blood pressure fell to a lower level in the completely denervated dogs than in the normal, vagotomized, or carotid denervated animals. It is therefore evident that neither the vagi nor afferent nerves at the carotid bifurcation is necessary for mediation of the bradycrotic response. The alseroxylon-induced hypotension is also not mediated via these nerves, but is, instead, slightly limited or buffered by the presence of either or both of these nervous pathways. Whether this buffering action is physiological or potentiated by the alseroxylon alkaloids is reported upon elsewhere in This Journal.
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