Rats administered chronic neuroleptics develop oral movements which are similar in form to those in humans with tardive dyskinesia
✍ Scribed by Gaylord Ellison; Ronald E. See
- Book ID
- 104775491
- Publisher
- Springer
- Year
- 1989
- Tongue
- English
- Weight
- 285 KB
- Volume
- 98
- Category
- Article
- ISSN
- 0033-3158
No coin nor oath required. For personal study only.
✦ Synopsis
Oral movements (OMs) in rats chronically administered haloperidol (HAL), fluphenazine (FLU), or no drug were recorded using a computerized video analysis system which measured the distance between two fluorescent dots painted above and below the rat's mouth. The resulting data was analyzed using fast-fourier analysis. Following an initial period of sedation (decreased energy at all frequencies), the drugged animals (and especially the FLU animals) began to show increased oral movements of 1-2 Hz, an effect which increased substantially upon drug withdrawal. This is precisely the altered energy spectrum observed in humans with tardive dyskinesia.