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Rationally Engineered Total Biosynthesis of a Synthetic Analogue of a Natural Quinomycin Depsipeptide in Escherichia coli

✍ Scribed by Kenji Watanabe; Kinya Hotta; Alex P. Praseuth; Mark Searcey; Clay C. C. Wang; Hiroki Oguri; Hideaki Oikawa

Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 267 KB
Volume: 10
Category: Article
ISSN: 1439-4227
DOI: 10.1002/cbic.200900260

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✦ Synopsis

Quinomycin antibiotics, such as echinomycin (1) and triostin A (2; [1] Scheme 1), are nonribosomally synthesized peptides char-Scheme 1. Structures of the natural quinomycin antibiotics echinomycin (1) and triostin A (2), and the synthetic antibiotic TANDEM (3).

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