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Rationalizing the membrane interactions of cationic amphipathic antimicrobial peptides by their molecular shape

✍ Scribed by Burkhard Bechinger


Book ID
108097393
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
843 KB
Volume
14
Category
Article
ISSN
1359-0294

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Membrane interactions of designed cation
✍ Evgenia Glukhov; Lori L. Burrows; Charles M. Deber 📂 Article 📅 2008 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 382 KB

## Abstract Novel cationic antimicrobial peptides (CAPs) designed in our lab—typified by sequences such as KKKKKKAAX‐AAXAAXAA‐NH~2~, where X = Phe/Trp—display high antibacterial activity but exhibit little or no hemolytic activity towards human red blood cells even at high doses. To clarify the mec