Rationale for use of cyclooxygenase-2 inhibitors in prevention and treatment of bladder cancer
β Scribed by Raj S. Pruthi; Eric Derksen; Kris Gaston; Eric M. Wallen
- Book ID
- 116944335
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 126 KB
- Volume
- 64
- Category
- Article
- ISSN
- 0090-4295
No coin nor oath required. For personal study only.
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## Abstract Cyclooxygenaseβ2 (COXβ2) is an inducible enzyme that regulates prostaglandin synthesis and is overexpressed at sites of inflammation and in several epithelial cancers. A causal link for COXβ2 in epithelial tumorigenesis was shown in genetically manipulated animal models of colon and bre
## Abstract The traditional nonsteroidal antiβinflammatory drugs (NSAIDs) exert their effect by inhibition of cyclooxygenaseβ1 (COXβ1) as well as COXβ2 enzymes. As COXβ1 is responsible for maintaining normal biological functions, the nonselective inhibition of these enzymes caused side effects incl