Rationale and clinical experience with epidermal growth factor receptor inhibitors in gynecologic malignancies
β Scribed by Ami P. Vaidya; Aric D. Parnes; Michael V. Seiden
- Book ID
- 107531903
- Publisher
- Springer
- Year
- 2005
- Tongue
- English
- Weight
- 339 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1527-2729
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Novel therapeutic agents that target the epidermal growth factor receptor (EGFR) constitute an important addition to the therapeutic armamentarium for the treatment of metastatic disease. EGFRβtargeted agents currently approved by the U.S. Food and Drug Administration include cetuximab,
Epidermal growth factor (EGF) and transforming growth factor-alpha (TGFo0 are two closely related peptides that interact with cell-surface epidermal growth factor receptors (EGFR) to induce receptor tyrosine phosphorylation and activation of intracellular signal-transduction pathways. EGF appears to