𝔖 Bobbio Scriptorium
✦   LIBER   ✦

RATIONAL DESIGN, SYNTHESIS, AND SERINE PROTEASE INHIBITORY ACTIVITY OF NOVEL P1-ARGININOYL HETEROCYCLES

✍ Scribed by Susan Y Tamura; Brian M Shamblin; Terence K Brunck; William C Ripka


Book ID
118606692
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
792 KB
Volume
7
Category
Article
ISSN
0960-894X

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


Rational design, synthesis, and serine p
✍ Susan Y. Tamura; Erick A. Goldman; Terence K. Brunck; William C. Ripka; J. Edwar πŸ“‚ Article πŸ“… 1997 πŸ› Elsevier Science 🌐 English βš– 406 KB

Based on molecular modeling and judicious combination of the salient topographic features of the recently discovered P3-1actam derivative 1 with the P2-prolyl derivatives 2a,b, the novel thrombin inhibitor 3a was designed. Inhibitor 3a incorporates a fused bicyclic lactam as a novel type of P2-P3 di

ChemInform Abstract: Rational Design, Sy
✍ S. Y. TAMURA; E. A. GOLDMAN; T. K. BRUNCK; W. C. RIPKA; J. E. SEMPLE πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 33 KB πŸ‘ 3 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a β€œFull Text” option. The original article is trackable v

Synthesis and biological activity of P2–
✍ J.Edward Semple; David C. Rowley; Terence K. Brunck; William C. Ripka πŸ“‚ Article πŸ“… 1997 πŸ› Elsevier Science 🌐 English βš– 388 KB

Molecular modeling and topographic considerations of the thrombin-specific sequences Boc-Asp-Pro-Arg-TS or Ac-d-Phe-Pro-Arg-TS (TS = transition state analog electrophilic center) and related scaffolds led to the design of novel P2-P4-azapeptidomimetic Pl-argininal and Pl-ketoargininamide derivatives