## Abstract Dysregulated angiogenesis is implicated in several pathologies, including cancer and age‐related macular degeneration. A potential antiangiogenic strategy consists in developing VEGF receptor ligands capable of preventing VEGF binding and the subsequent activation of these receptors. He
✦ LIBER ✦
Rational Design, Structure, and Biological Evaluation of Cyclic Peptides Mimicking the Vascular Endothelial Growth Factor
✍ Scribed by Goncalves, Victor; Gautier, Benoit; Coric, Pascale; Bouaziz, Serge; Lenoir, Christine; Garbay, Christiane; Vidal, Michel; Inguimbert, Nicolas
- Book ID
- 119998680
- Publisher
- American Chemical Society
- Year
- 2007
- Tongue
- English
- Weight
- 545 KB
- Volume
- 50
- Category
- Article
- ISSN
- 0022-2623
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## Abstract The (3__R__,5__S__,6__E__,8__S__,10__R__)‐11‐amino‐3,5,8,10‐tetramethylundec‐6‐enoic acid (ATUA; **1**), which was designed as a __β__II′‐turn mimic according to the concepts of allylic strain and 2,4‐dimethylpentane units, was incorporated into a cyclic RGD peptide. The three‐dimension