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Rational design and synthesis of unsaturated 2,5-dioxopiperazine derivatives as potential protein tyrosine kinase inhibitors

✍ Scribed by Wen-Ren Li; Shao-Zheng Peng

Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
234 KB
Volume
39
Category
Article
ISSN
0040-4039

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✦ Synopsis

The first general method for the synthesis of a library of trifunctionalized (Z)-3-alkylidene-2,5-piperazinediones as potential protein tyrosine kinase inhibitors from commercially available amino compounds, ot-keto acids and aldehydes using a novel cyclization/cleavage strategy on solid support is described.

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