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Rational design and synthesis of a double-stranded DNA–binder library

✍ Scribed by Jaroslav S̆ebestík; Jan Hlavác̆ek; Ivan Stibor

Publisher: Wiley (John Wiley & Sons)
Year: 2006
Tongue: English
Weight: 169 KB
Volume: 84
Category: Article
ISSN: 0006-3525
DOI: 10.1002/bip.20487

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✦ Synopsis

Abstract

Described is a computer‐assisted rational design of a DNA–bis‐intercalator peptide library. The peptide library of 250 members was prepared and the most powerful binder identified. A value of the binding constant is almost two orders of magnitude higher than that of starting building block‐9‐aminoacridine. The binder affinity found toward calf thymus DNA is 30‐fold of that of human prion peptide 106–126. © 2006 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 84: 400–407, 2006

This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at [email protected]

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