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Rational Design and Engineered Biosynthesis of a Novel 18-Carbon Aromatic Polyketide

โœ Scribed by Kramer, Peter J.; Zawada, Robert J. X.; McDaniel, Robert; Hutchinson, C. Richard; Hopwood, David A.; Khosla, Chaitan


Book ID
127013792
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
250 KB
Volume
119
Category
Article
ISSN
0002-7863

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Engineered biosynthesis of novel polyket
โœ Hong Fu; David A. Hopwood; Chaitan Khosla ๐Ÿ“‚ Article ๐Ÿ“… 1994 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 662 KB

## Background: Aromatic polyketide synthases (PKSs) catalyze the formation and cyclization of polyketide chains of variable lengths, generating a family of compounds of proven medical significance. Initial control over the regiospecificity of cyclization is believed to be exercised by the minimal