Engineered biosynthesis of novel polyket
โ
Hong Fu; David A. Hopwood; Chaitan Khosla
๐
Article
๐
1994
๐
Elsevier Science
๐
English
โ 662 KB
## Background: Aromatic polyketide synthases (PKSs) catalyze the formation and cyclization of polyketide chains of variable lengths, generating a family of compounds of proven medical significance. Initial control over the regiospecificity of cyclization is believed to be exercised by the minimal