Rate studies on the hydrolysis of niacinamide
โ Scribed by Per Finholt; Takeru Higuchi
- Publisher
- John Wiley and Sons
- Year
- 1962
- Tongue
- English
- Weight
- 526 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0022-3549
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๐ SIMILAR VOLUMES
The mechanism of the A2 acid hydrolysis of methyl carbamate was investigated using MNDO method. The reaction was found to proceed in two steps: (1) the rate-determining nucleophilic attack of water on the carbonyl carbon of the N-protonated tautomer involving the tetrahedral TS; and (2) the fast sub
The reaction mechanisms of the alkaline hydrolysis of N-methylcarbamates were studied using the AM1 method by assuming two possible pathways: (1) nucleophilic attack of hydroxide ion on the car-bony1 carbon to give a tetrahedral complex followed by its breakdown to carbamic acid (BA,~); and (2) prot