Rate of decline in renal function in Indo-Asians and Whites with diabetic nephropathy

✍ Scribed by Koppiker, N.; Feehally, J.; Raymond, N.; Abrams, K.R.; Burden, A.C.

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 87 KB
• Volume: 15
• Category: Article
• ISSN: 0742-3071
• DOI: 10.1002/(sici)1096-9136(199801)15:1<60::aid-dia525>3.0.co;2-r

✦ Synopsis

The incidence of end-stage renal failure (ESRF) is higher in the Indo-Asian ethnic group as compared to the White. To investigate whether this might be associated with faster rates of progression to ESRF in Indo-Asian diabetic patients, we studied a total of 39 Type 2 diabetic patients, using the Department of Nephrology database showing serial serum creatinine measurements from the time of first referral to the clinic until they reached a level of Ͼ500 mol l ؊1 or ESRF requiring renal replacement therapy (RRT), either dialysis or renal transplantation. They were grouped into Indo-Asian (n ‫؍‬ 24) and White (n ‫؍‬ 15). The rate of progression of those who developed ESRF, calculated as the slope of log serum creatinine against time, was not significantly different between the Indo-Asian and White patients, p ‫؍‬ 0.73. We conclude that the higher incidence of ESRF in the Indo-Asian Type 2 diabetic patient with nephropathy is therefore not due to a faster rate of deterioration in renal function.