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Rate-limiting steps in the interactions of fluoropyrimidines and methotrexate

โœ Scribed by Bowen, Donnell; Bailey, Brenda D.; Guernsey, Linda A.


Book ID
120975213
Publisher
Elsevier Science
Year
1984
Weight
801 KB
Volume
20
Category
Article
ISSN
0277-5379

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โœ Tugrul T. Kararli; James Stolzenbach ๐Ÿ“‚ Article ๐Ÿ“… 1992 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 415 KB

Oral administration of a leucotriene D4 antagonist drug (1) in the Beagle dog at doses of 2, 20, 100, 300, and 800 mg/kg resulted in dose-dependent bioavailability values (4-50%). To understand the dose dependence of the absorption of 1 in the dog, initial rates of absorption of 1, which were estima