Rate Acceleration of the Reaction between Solid Reactants by Premixing in Solution: Application to the Efficient Synthesis of a [2]Rotaxane

✍ Scribed by Akihiro Orita; Junji Okano; Yoshiki Tawa; Lasheng Jiang; Junzo Otera

• Publisher: John Wiley and Sons
• Year: 2004
• Tongue: English
• Weight: 126 KB
• Volume: 43
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/anie.200460062

✦ Synopsis

Solventless reactions are currently a subject of extensive interest in both inorganic and organic chemistry. [1] In particular, organic synthesis may benefit from avoiding the use of organic solvents, yet this is valid only if a whole process, including work-up operations, is free from organic solvents. The higher efficiencies and selectivities frequently encountered under solventless conditions are of prime significance in terms of organic synthesis and process chemistry. Many common organic reactions are accelerated under solventless conditions, and we also previously disclosed dramatic rate enhancement for supramolecular self-assembly. [2,3] Most reactions between solid reactants demand mechanical forces such as grinding in a mortar with a pestle or compounding in a ball mill. [4] The reaction generally proceeds through formation of a liquid or melt phase containing an intimate mixture