Rat α1F. XI. Immunological control of cell proliferation: Increased growth rate and α1F production by morris hepatoma 5123tc in rats treated with anti-thymocyte serum
✍ Scribed by P. Bernstein; H. T. Wepsic; S. Sell
- Publisher
- John Wiley and Sons
- Year
- 1974
- Tongue
- French
- Weight
- 635 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0020-7136
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✦ Synopsis
The administration of anti-thymocyte serum ( A T S ) to rats bearing transplantable Morris hepatoma 5123tc resulted in an increase in the growth rate of the tumor and in the rate of alpha,fetoprotein (u,F) production by the tumor. ATS-treated rats not only had faster growing tumors and correspondingly higher serum a,F concentrations than untreated 5123tc tumor-bearing rats, but also the amount of a,F per gram of tumor tissue was significantly greater. I n addition, the mitotic index of tumors in ATS-treated animals was twice that of the tumors in control animals. The results indicate that the rate of a,F production by hepatomas that have the capacity to synthetize a,F is directly related to the number of proliferating cells present at any given