We have demonstrated that a 40% restriction of dietary energy consumption virtually abolishes the development of prolactin (PRL)-producing pituitary tumors in Fischer 344 (F344) rats treated chronically with estrogen, apparently by inhibiting the ability of estrogen to enhance survival within a rapi
โฆ LIBER โฆ
Rat strain specific attenuation of estrogen action in the anterior pituitary gland by dietary energy restriction
โ Scribed by Djuana M. E. Harvell; Linda K. Buckles; Karen A. Gould; Karen L. Pennington; Rodney D. McComb; James D. Shull
- Book ID
- 111637905
- Publisher
- Springer
- Year
- 2003
- Tongue
- English
- Weight
- 557 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0969-711X
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Our laboratory is examining the hypothesis that diet may modulate the ability of estrogens to regulate cell proliferation and survival, either of which could affect development of neoplasms in estrogen-responsive tissues. In this study, we examined whether the amount of energy and protein consumed i