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Rat Skeletal Myoblasts and Arterial Smooth Muscle Cells Express the Gene for the A Chain but not the Gene for the B Chain (c-sis) of Platelet-Derived Growth Factor (PDGF) and Produce a PDGF-Like Protein

✍ Scribed by Thomas Sejersen, Christer Betsholtz, Maria Sjölund, Carl-Henrik Heldin, Bengt Westermark and Johan Thyberg


Book ID
123633322
Publisher
National Academy of Sciences
Year
1986
Tongue
English
Weight
842 KB
Volume
83
Category
Article
ISSN
0027-8424

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Proliferation of smooth muscle cells (SMC) in the arterial intima of man and experimental animals is important in the pathogenesis of atherosclerosis. Vascular SMC proliferation in vitro is stimulated by a number of agents, including the potent protein mitogen, platelet-derived growth factor (PDGF).