Rat retinal ganglion cells co-express brain derived neurotrophic factor (BDNF) and its receptor TrkB
✍ Scribed by Elena Vecino; David Garcı́a-Grespo; Mónica Garcı́a; Luis Martinez-Millán; Sansar C Sharma; Eliseo Carrascal
- Book ID
- 117240136
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 277 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0042-6989
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Adult rat retinal ganglion cells (RGC) undergo degeneration after optic nerve transection. Studies have shown that exogenously applied neurotrophic factors such as brain-derived neurotrophic factor (BDNF) can attenuate axotomy-induced as well as developmental RGC death. Here, we examined whether gli
The tyrosine kinase TrkB is a receptor for the neurotrophic factors brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT-4). Retinal ganglion cells are responsive to BDNF, and TrkB has been localized in ganglion cells as well as in a subpopulation of amacrine cells in the retina of the ch