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Rat liver uridine diphosphate glucose dehydrogenase: Dual mechanism of regulation in vivo

✍ Scribed by S.M. Kelkar

Book ID
115707074
Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
378 KB
Volume
246
Category
Article
ISSN
0003-9861

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Our earlier studies have shown that in normal hepatocytes, orotic acid (OA) inhibits DNA synthesis induced by several growth factors in vitro and after two-thirds partial hepatectomy (PH) in vivo. As in the normal liver OA induces an imbalance in nucleotide pools (specifically, an increase in uridin