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Rat liver-mediated metabolism of hydroxyurea to nitric oxide

✍ Scribed by Jinming Huang; Mamudu Yakubu; Daniel B. Kim-Shapiro; S. Bruce King

Book ID
113629892
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
271 KB
Volume
40
Category
Article
ISSN
0891-5849

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Nitric oxide (NO) can be either cytoprotective or cytotoxic in hepatocytes, depending on conditions within the cell. We hypothesized that redox status is a determinant of NO effects on cell viability. To cause the disturbance of redox homeostasis in the hepatocytes, cells were treated with the follo