𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Rat Growth-Hormone Release Stimulators from Fenugreek Seeds

✍ Scribed by Sang Hee Shim; Eun Ju Lee; Ju Sun Kim; Sam Sik Kang; Hyekyung Ha; Ho Young Lee; Chungsook Kim; Je-Hyun Lee; Kun Ho Son

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
194 KB
Volume
5
Category
Article
ISSN
1612-1872

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Bioassay‐guided fractionation of MeOH extract from fenugreek (Trigonella foenum‐graecum L.) seeds resulted in the isolation of two rat growth‐hormone release stimulators in vitro, fenugreek saponin I (1) and dioscin (9), along with two new, i.e., 2 and 3, and five known analogues, i.e., 4–8. The structures of the new steroidal saponins, fenugreek saponins I, II, and III (1–3, resp.), were determined as gitogenin 3‐O‐β‐D‐xylopyranosyl‐(1→6)‐β‐D‐glucopyranoside, sarsasapogenin 3‐O‐β‐D‐xylopyranosyl‐(1→6)‐β‐D‐glucopyranoside, and gitogenin 3‐O‐α‐L‐rhamnopyranosyl‐(1→2)‐β‐D‐glucopyranoside, respectively. Fenugreek saponin I (1) and dioscin (9) caused ca. 12.5‐ and 17.7‐fold stimulation of release, respectively, of rat growth hormone from rat pituitary cells, whereas gitogenin (5) showed moderate activity. To our knowledge, this is the first study to demonstrate that steroidal saponins stimulate rat growth‐hormone release in rat pituitary cells.

📜 SIMILAR VOLUMES

Human pancreatic growth hormone-releasin
Human pancreatic growth hormone-releasing factor (hpGRF) stimulates growth hormone release in goldfish
✍ Peter, Richard E. ;Nahorniak, Carol S. ;Vale, Wylie W. ;Rivier, Jean E. 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 English ⚖ 228 KB

## Abstract Synthetic human pancreatic growth hormone‐releasing factor (hpGRF) was injected intraperitoneally in different dosages, either as one injection or two injections 3 hours apart, into goldfish. Serum GH levels were increased by certain dosages of hpGRF under both treatments. This is the f

Localization of growth hormone-release-i
Localization of growth hormone-release-inhibiting hormone (somatostatin) in the rat brain
✍ Pelletier, Georges ;Leclerc, Rachel ;Dube, Donald ;Labrie, Fernand ;Puviani, Rom 📂 Article 📅 1975 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 288 KB 👁 2 views

## Abstract Utilizing an immunoperoxidase technique at the light microscope level, growth hormone‐release‐inhibiting hormone (somatostatin) was localized in the external zone of the median eminence, the subcommissural organ, the organum vasculosum of the lamina terminal is and the pineal gland. No

Internalization and trafficking of the h
Internalization and trafficking of the human and rat growth hormone-releasing hormone receptor
✍ Christelle Veyrat-Durebex; Luc Pomerleau; Daniel Langlois; Pierrette Gaudreau 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 347 KB

## Abstract Internalization and intracellular trafficking of the growth hormone‐releasing hormone receptor (GHRH‐R) were studied in rat anterior pituitary and human (h) and rat (r) GHRH‐R‐transfected BHK cells, with the GHRH agonist, [N^α^‐5‐carboxyfluoresceinyl‐D‐Ala^2^, Ala^8^, Ala^15^, Lys^22^]h

Hypoxia stimulates vesicular ATP release
Hypoxia stimulates vesicular ATP release from rat osteoblasts
✍ Isabel R. Orriss; Gillian E. Knight; Jennifer C. Utting; Sarah E.B. Taylor; Geof 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 278 KB

## Abstract Many neuronal and non‐neuronal cell types release ATP in a controlled manner. After release, extracellular ATP (or, following hydrolysis, ADP) acts on cells in a paracrine manner via P2 receptors. Extracellular nucleotides are now thought to play an important role in the regulation of b

THYROID-STIMULATING HORMONE AND GROWTH H
THYROID-STIMULATING HORMONE AND GROWTH HORMONE RELEASE ALTERATIONS INDUCED BY MOSQUITO LARVAE PROTEINS ON PITUITARY CELLS
✍ Federico Bolognani; Rodolfo Gustavo Goya; Jorge Rafael Ronderos 📂 Article 📅 2001 🏛 Elsevier Science 🌐 English ⚖ 128 KB

Mosquito larvae crude extract has shown to modulate cell proliferation of different mouse epithelial as well as human mononuclear cell populations __in vivo__ and __in vitro__. A soluble fraction of the extract, with a molecular weight ranging from 12 to 80kD, also showed an inhibitory effect on the