Ras signalling is required for inactivation of the tumour suppressor pRb cell-cycle control protein

PAK4 is required for regulation of the c

PAK4 is required for regulation of the cell-cycle regulatory protein p21, and for control of cell-cycle progression

✍ Tanya Nekrasova; Dr. Audrey Minden 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 979 KB

## Abstract The serine/threonine kinase PAK4 regulates cytoskeletal architecture, and controls cell proliferation and survival. In most adult tissues PAK4 is expressed at low levels, but overexpression of PAK4 is associated with uncontrolled proliferation, inappropriate cell survival, and oncogenic