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ras oncogene mutations in diethylnitrosamine-induced hepatic tumors in medaka (Oryzias latipes), a teleost fish

✍ Scribed by Zi Liu; Seth W. Kullman; David C. Bencic; Michael Torten; David E. Hinton


Book ID
117767162
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
200 KB
Volume
539
Category
Article
ISSN
1383-5718

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## Abstract Hepatic tumors were generated in mice by repeated administration of carbon tetrachloride (CCI~4~). Eight transgenic (Tg) mice carrying a human c‐H‐__ras__ proto‐oncogene (rasH2 line) and 9 non‐Tg mice were killed at 20 weeks. Tg mice developed more tumors than did non‐Tg littermates. Mo