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Rarity of dominant-negative mutations of the G-CSF receptor in patients with blast crisis of chronic myeloid leukemia or de novo acute leukemia

โœ Scribed by Carapeti, M; Soede-Bobok, A; Hochhaus, A; Sill, H; Touw, I P; Goldman, J M; Cross, N C P


Book ID
110053547
Publisher
Nature Publishing Group
Year
1997
Tongue
English
Weight
268 KB
Volume
11
Category
Article
ISSN
0887-6924

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## Abstract A myeloid leukemia cell line designated Kasumiโ€6 was established from the bone marrow cells of an individual with acute myeloid leukemia, subtype M2. Both the original leukemic cells and the Kasumiโ€6 cell line harbor a hemizygous point mutation in the gene encoding the CCAAT/enhancer bi