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Rare, Structurally Homologous Self-Peptides Promote Thymocyte Positive Selection

✍ Scribed by Fabio R Santori; William C Kieper; Stuart M Brown; Yun Lu; Thomas A Neubert; Kenneth L Johnson; Stephen Naylor; Stanislav Vukmanović; Kristin A Hogquist; Stephen C Jameson

Book ID
117723254
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
777 KB
Volume
17
Category
Article
ISSN
1074-7613

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## Peptide antagonists that promote positive selection are inefficient at T cell activation and thymocyte deletion* We set out to determine whether thymocytes from Tcell receptor (TCR) transgenic animals specific for a class I-restricted determinant from ovalbumin (OVA) showed the same fine specif