Rare occurrence of inactivating p53 gene mutations in primary non-astrocytic tumors of the central nervous system: reappraisal by yeast functional assay

Clonality and stability of the p53 gene

Clonality and stability of the p53 gene in human astrocytic tumor cells: Quantitative analysis of p53 gene mutations by yeast functional assay

✍ Mitsuhiro Tada; Richard D. Iggo; Nobuaki Ishii; Yumiko Shinohe; Shirou Sakuma; A 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 French ⚖ 437 KB 👁 2 views

Mutation of the p53 gene is found in about one third of astrocytic brain tumors, and expansion of tumor cell clones containing mutant p53 has been implicated in astrocytic tumor progression. However, admixture of normal cells in astrocytic tumor specimens limits the power of traditional studies of t