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Rare and low-frequency coding variants in CXCR2 and other genes are associated with hematological traits

✍ Scribed by Auer, Paul L; Teumer, Alexander; Schick, Ursula; O'Shaughnessy, Andrew; Lo, Ken Sin; Chami, Nathalie; Carlson, Chris; de Denus, Simon; Dubé, Marie-Pierre; Haessler, Jeff; Jackson, Rebecca D; Kooperberg, Charles; Perreault, Louis-Philippe Lemieux; Nauck, Matthias; Peters, Ulrike; Rioux, John D; Schmidt, Frank; Turcot, Valérie; Völker, Uwe; Völzke, Henry; Greinacher, Andreas; Hsu, Li; Tardif, Jean-Claude; Diaz, George A; Reiner, Alexander P; Lettre, Guillaume


Book ID
125427878
Publisher
Nature Publishing Group
Year
2014
Tongue
English
Weight
770 KB
Volume
46
Category
Article
ISSN
1061-4036

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✍ Carrie M Nielson; Joseph M Zmuda; Amy S Carlos; Wendy J Wagoner; Emily A Larson; 📂 Article 📅 2011 🏛 American Society for Bone and Mineral Research 🌐 English ⚖ 415 KB

## Abstract Alkaline phosphatase (ALP) plays an essential role in the regulation of tissue mineralization, and its activity is highly heritable. Guided by genetic associations discovered in a murine model, we hypothesized a role for rare coding variants in determining serum ALP level and bone miner